Department of Medicine and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
PI: Jacqueline M. Achkar, M.D., M.Sc., FIDSA
A position is open for the study of human protective and non-protective antibody responses to M. tuberculosis.
This will be especially of interest for applicants who want to expand or gain experience in translational research. Specific interests of the laboratory include understanding the role of the human humoral immune response to M. tuberculosis
in patients at various states of infection. These include i) large scale tuberculosis serology studies using innovative techniques to identify both antibodies that can serve as tuberculosis biomarker as well as antibodies with protective functions, ii) isolation and generation of polyclonal and monoclonal human antibodies to M. tuberculosis
antigens, and iii) detailed studies of antibody mechanism against M. tuberculosis in vitro
and in vivo
. Candidates should have a strong background in Immunology and/or Microbiology.
Dr. Achkar's translational research program is focused on the evaluation of immune and other host responses to Mycobacterium tuberculosis in patients at various states of infection towards i) the development of better serodiagnostic tests for active tuberculosis (TB); ii) the prediction of TB development in HIV+ subjects; iii) the study of protective antibody functions against M. tuberculosis; and iv) the identification of host responses that correlate with TB vaccine effectiveness. Dr. Achkar is an NIH funded physician scientist with expertise in human immune responses to TB. She has many national and international collaborations with investigators from a broad range of expertise such as clinical trials/research, biodesign, biochemistry, epidemiology, and biostatistics. As a specialist in Infectious Diseases with an additional master's degree in clinical research methods, Dr. Achkar analyses her laboratory data in the context of clinical findings to contribute critical data to the field of TB diagnostics, immunotherapy, and vaccine development.
The Albert Einstein College of Medicine is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.
- Ph.D. or M.D./Ph.D. in Immunology or Microbiology
- Broad skill base in standard techniques such as (ELISA, Western Blot, DNA and RNA extraction, PCR, and protein purification)
- Strong record of research experience and productivity
- Excellent interpersonal and organizational skills
- Excellent record keeping and data presentation
- Expertise in flow cytometry and FACS
- Expertise in B-cell immunology and in vitro assay development (ADCC, CDC, etc.)
- Expertise in protein engineering (B-cell cloning, expression, purification), microarray, and bioinformatics.
- Experience with in vivo models of infectious diseases
Compensation as per NIH guidelines.